RNA Transcription and Maturation in Skeletal Muscle Cells are Similarly Impaired in Myotonic Dystrophy and Sarcopenia: The Ultrastructural Evidence
نویسندگان
چکیده
1 Anatomy and Histology Section, Department of Neurological and Movement Sciences, University of Verona, Verona, Italy 2 Laboratory of Muscle Histopathology and Molecular Biology, IRCCS-Policlinico San Donato, Milan, Italy 3 Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology, University of Pavia, Pavia, Italy 4 Department of Neurology, University of Milan, Milan, Italy *Correspondence: [email protected]
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Structural and functional alterations of the cell nucleus in skeletal muscle wasting: the evidence in situ
The histochemical and ultrastructural analysis of the nuclear components involved in RNA transcription and splicing can reveal the occurrence of cellular dysfunctions eventually related to the onset of a pathological phenotype. In recent years, nuclear histochemistry at light and electron microscopy has increasingly been used to investigate the basic mechanisms of skeletal muscle diseases; the ...
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